Researchers

An overview of our research

infographic explaining how steatoSITE data collection works

All data points in SteatoSITE are annotated with a time relative to the date of the biopsy or surgery that generated the histological specimen. This allows all data to be conceptualised as case-specific timelines, all anchored around the tissue date (time ‘0’), from 10 years before the date of the tissue up to May 2020. 

Data Summary

  • Demographics (age, sex, ethnicity, SIMD)
  • Co-morbidities (cardiometabolic diseases, cancers)
  • Laboratory tests (including biochemistry, haematology, liver screen)
  • FibroScan® results (if performed)
  • Liver related and co-morbid clinical events, procedures and outcomes; deaths
  • Prescribed medications

Histopathology

  • Whole-slide scans (x40) of Haematoxylin and Eosin and Picro-Sirius Red stained sections from Leica GT450DX scanner.
  • NASH-CRN NAFLD Activity Score (NAS) and fibrosis stage; Steatosis, Activity, Fibrosis (SAF) scores; modified Ishak score assigned by Consultant Histopathologist panel (National liver EQA members).
  • Percentage steatosis and fibrosis determined by application of machine-learning pixel classifier using QuPath. 

Transcriptomics

  • Successful hepatic bulk RNA-seq data on 668 and 39 (normal liver) control cases. Raw RNA-seq data (FASTQ files) and minimal metadata (fibrosis stage) is available at the European Nucleotide Archive (accession number:/ link).

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