Publications

Late-Stage Minimal Labeling of Peptides and Proteins for Real-Time Imaging of Cellular Trafficking, F. Nadal-Bufi, R. V. Nithun, F. De Moliner, X. Lin, S. Habiballah, M. Jbara and M. Vendrell, ACS Cent. Sci., 2024, acscentsci.4c01249. http://doi.org/10.1021/acscentsci.4c01249

Label-Free SERS Sensors for Real-Time Monitoring of Tyrosine Phosphorylation, A. Geddis, L. Mendive-Tapia, A. Sujantho, E. Liu, S. McAughtrie, R. Goodwin, M. Vendrell and C. J. Campbell, Anal. Chem., 2024, 96, 17978–17983. http://doi.org/10.1021/acs.analchem.4c02860

Chemo-Click: Receptor-Controlled and Bioorthogonal Chemokine Ligation for Real-Time Imaging of Drug-Resistant Leukemic B Cells, M. Bertolini, L. Mendive-Tapia, U. Karmakar and M. Vendrell, J. Am. Chem. Soc., 2024, 146, 30565–30572. http://doi.org/10.1021/jacs.4c12035

Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial, S. Pal, J. Chataway, R. Swingler, M. R. Macleod, N. O. Carragher, G. Hardingham, B. T. Selvaraj, C. Smith, C. Wong, J. Newton, D. Lyle, A. Stenson, R. S. Dakin, A. Ihenacho, S. Colville, A. R. Mehta, N. Stallard, J. R. Carpenter, R. A. Parker, C. Keerie, C. J. Weir, B. Virgo, S. Morris, N. Waters, B. Gray, D. MacDonald, E. MacDonald, M. K. B. Parmar, S. Chandran, G. Gorrie, I. Morrison, C. Duncan, J. Carod Artal, T. Williams, V. Srinivasan, A. Radunovic, A. Pinto, H. Hamdalla, R. Roberts, P. Garcia- Reitboeck, T. Harrower, G. Mamutse, F. Crawley, C. Galton, K. Dawson, R. Forbes, C. Hillier, C. McDermott, D. Forbes, H. Bozkurt, M. Stavrou, P. Kearns, D. Breen, H. Kurucu King, E. Elliot, E. Beswick, J. Williamson, P. Cucurachi and L. McLennan, The Lancet Neurology, 2024, 23, 1097–1107. http://doi.org/10.1016/S1474-4422(24)00326-0

Rapid discovery and evolution of nanosensors containing fluorogenic amino acids, E. Kuru, J. Rittichier, H. De Puig, A. Flores, S. Rout, I. Han, A. E. Reese, T. M. Bartlett, F. De Moliner, S. G. Bernier, J. D. Galpin, J. Marchand, W. Bedell, L. Robinson-McCarthy, C. A. Ahern, T. G. Bernhardt, D. Z. Rudner, J. J. Collins, M. Vendrell and G. M. Church, Nat Commun, 2024, 15, 7531. http://doi.org/10.1038/s41467-024-50956-z

Tuning singlet oxygen generation with caged organic photosensitizers, E. Nestoros, F. De Moliner, F. Nadal-Bufi, D. Seah, M. C. Ortega-Liebana, Z. Cheng, S. Benson, C. Adam, L. Maierhofer, K. Kozoriz, J.-S. Lee, A. Unciti-Broceta and M. Vendrell, Nat Commun, 2024, 15, 7689. http://doi.org/10.1038/s41467-024-51872-y

An ILK/STAT3 pathway controls glioblastoma stem cell plasticity, A. E. P. Loftus, M. S. Romano, A. N. Phuong, B. J. McKinnel, M. T. Muir, M. Furqan, J. C. Dawson, L. Avalle, A. T. Douglas, R. L. Mort, A. Byron, N. O. Carragher, S. M. Pollard, V. G. Brunton and M. C. Frame, Developmental Cell, 2024, S1534580724005318. http://doi.org/10.1016/j.devcel.2024.09.003

The SRC family kinase inhibitor NXP900 demonstrates potent antitumor activity in squamous cell carcinomas, S. Dash, S. Hanson, B. King, K. Nyswaner, K. Foss, N. Tesi, M. J. B. Harvey, S. A. Navarro-Marchal, A. Woods, E. Poradosu, A. Unciti-Broceta, N. O. Carragher and J. Brognard, Journal of Biological Chemistry, 2024, 300, 107615. http://doi.org/10.1016/j.jbc.2024.107615

Photosensitizer‐Amplified Antimicrobial Materials for Broad‐Spectrum Ablation of Resistant Pathogens in Ocular Infections, C. Lochenie, S. Duncan, Y. Zhou, L. Fingerhut, A. Kiang, S. Benson, G. Jiang, X. Liu, B. Mills and M. Vendrell, Advanced Materials, 2024, 36, 2404107. http://doi.org/10.1002/adma.202404107

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB₁ R), L. Mach, A. Omran, J. Bouma, S. Radetzki, D. A. Sykes, W. Guba, X. Li, C. Höffelmeyer, A. Hentsch, T. Gazzi, Y. Mostinski, M. Wasinska-Kalwa, F. De Molnier, C. Van Der Horst, J. P. Von Kries, M. Vendrell, T. Hua, D. B. Veprintsev, L. H. Heitman, U. Grether and M. Nazare, J. Med. Chem., 2024, 67, 11841–11867. http://doi.org/10.1021/acs.jmedchem.4c00465

Enzyme‐Activatable Near‐Infrared Hemicyanines as Modular Scaffolds for in vivo Photodynamic Therapy,  Z. Cheng, S. Benson, L. Mendive‐Tapia, E. Nestoros, C. Lochenie, D. Seah, K. Y. Chang, Y. Feng and M. Vendrell, Angew Chem Int Ed, 2024, 63, e202404587. http://doi.org/10.1002/anie.202404587

Sequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex, K. Morris, E. Bulovaite, T. Kaizuka, S. Schnorrenberg, C. Adams, N. H. Komiyama, L. Mendive-Tapia, S. G. Grant and M. H. Horrocks, 2024, preprint, DOI: 10.7554/eLife.99303.1. http://doi.org/10.7554/eLife.99303.1

Multimodal decoding of human liver regeneration, K. P. Matchett, J. R. Wilson-Kanamori, J. R. Portman, C. A. Kapourani, F. Fercoq, S. May, E. Zajdel, M. Beltran, E. F. Sutherland, J. B. G. Mackey, M. Brice, G. C. Wilson, S. J. Wallace, L. Kitto, N. T. Younger, R. Dobie, D. J. Mole, G. C. Oniscu, S. J. Wigmore, P. Ramachandran, C. A. Vallejos, N. O. Carragher, M. M. Saeidinejad, A. Quaglia, R. Jalan, K. J. Simpson, T. J. Kendall, J. A. Rule, W. M. Lee, M. Hoare, C. J. Weston, J. C. Marioni, S. A. Teichmann, T. G. Bird, L. M. Carlin and N. C. Henderson, Nature, 2024, 630, 158–165. http://doi.org/10.1038/s41586-024-07376-2

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS, H. Spence, F. M. Waldron, R. S. Saleeb, A.-L. Brown, O. M. Rifai, M. Gilodi, F. Read, K. Roberts, G. Milne, D. Wilkinson, J. O’Shaughnessy, A. Pastore, P. Fratta, N. Shneider, G. G. Tartaglia, E. Zacco, M. H. Horrocks and J. M. Gregory, Acta Neuropathol, 2024, 147, 50. http://doi.org/10.1007/s00401-024-02705-1

Recent advances in minimal fluorescent probes for optical imaging, F. De Moliner, F. Nadal-Bufi and M. Vendrell, Current Opinion in Chemical Biology, 2024, 80, 102458. http://doi.org/10.1016/j.cbpa.2024.102458

SERS Microsensors for the Study of pH Regulation in Cystic Fibrosis Patient-Derived Airway Cultures, W. H. Skinner, N. Robinson, G. R. Hardisty, R. D. Gray and C. J. Campbell, ACS Sens., 2024, 9, 2550–2557. http://doi.org/10.1021/acssensors.4c00279

Brought to Light: A Fluorogenic Probe to Monitor Immunosuppressants, M. Werner and F. Thomas, ACS Cent. Sci., 2024, 10, 953–955. http://doi.org/10.1021/acscentsci.4c00665

Nonperturbative Fluorogenic Labeling of Immunophilins Enables the Wash-free Detection of Immunosuppressants, M. Bertolini, L. Mendive-Tapia, O. Ghashghaei, A. Reese, C. Lochenie, A. M. Schoepf, M. Sintes, K. Tokarczyk, Z. Nare, A. D. Scott, S. R. Knight, A. R. Aithal, A. Sachdeva, R. Lavilla and M. Vendrell, ACS Cent. Sci., 2024, 10, 969–977. http://doi.org/10.1021/acscentsci.3c01590

Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases A. Senan-Salinas, L. Comas, P. Esteban, M. Garzón-Tituaña, Z. Cheng, L. Santiago, M. P. Domingo, A. Ramírez-Labrada, J. R. Paño-Pardo, M. Vendrell, J. Pardo, M. A. Arias and E. M. Galvez, ACS Pharmacol. Transl. Sci., 2024, 7, 1474–1484. http://doi.org/10.1021/acsptsci.4c00065

Novel dual antimicrobial-imaging photodynamic therapy agent labels and kills AMR gram-positive bacteria, A. Kiang, S. Benson, C. Lochenie, S. Duncan, S. M. P. C. Mohanan, G. O. S. Williams, K. Dhaliwal, M. Vendrell and B. Mills, in Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, SPIE, 2024, vol. PC12822, p. PC1282207. http://doi.org/10.1117/12.3001408

P017 An activity-based chemiluminescence assay targeting granzyme A for the detection of Inflammatory Bowel Diseases, J. Scott, E. Thompson, Z. Cheng, M. David, D. Gordon, L. Medive-Tapia, G. R. Jones, R. Hall, S. Chuah, B. Drury, A. Rossi, D. Shabat, G. T. Ho and M. Vendrell, Journal of Crohn’s and Colitis, 2024, 18, i267–i268. http://doi.org/10.1093/ecco-jcc/jjad212.0147

Inserting “OFF-to-ON” BODIPY Tags into Cytokines: A Fluorogenic Interleukin IL-33 for Real-Time Imaging of Immune Cells, A. E. Reese, F. De Moliner, L. Mendive-Tapia, S. Benson, E. Kuru, T. Bridge, J. Richards, J. Rittichier, T. Kitamura, A. Sachdeva, H. J. McSorley and M. Vendrell, ACS Cent. Sci., 2024, 10, 143–154. http://doi.org/10.1021/acscentsci.3c01125

Single-molecule imaging of aquaporin-4 array dynamics in astrocytes, A.-L. Zepernick, V. Metodieva, N. Pelegrina-Hidalgo, A. H. Lippert, M. H. Horrocks and J. A. Varela, Nanoscale, 2024, 16, 9576–9582. http://doi.org/10.1039/D4NR00330F

No-wash fluorogenic labeling of proteins for reversible photoswitching in live cells, K. Torii, S. Benson, Y. Hori, M. Vendrell and K. Kikuchi, Chem. Sci., 2024, 15, 1393–1401. http://doi.org/10.1039/D3SC04953A

Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer, C. C. Ayala-Aguilera, Y. Ge, Á. Lorente-Macías, B. N. Jones, C. Adam, N. O. Carragher and A. Unciti-Broceta, RSC Med. Chem., 2024, 10.1039.D4MD00579A. http://doi.org/10.1039/D4MD00579A

A cautionary note on the use of N-acetylcysteine as a reactive oxygen species antagonist to assess copper mediated cell death, R. E. Graham, R. J. R. Elliott, A. F. Munro and N. O. Carragher, PLoS ONE, 2023, 18, e0294297. http://doi.org/10.1371/journal.pone.0294297

Imaging Proteins Sensitive to Direct Fusions Using Transient Peptide–Peptide Interactions, Z. Gidden, C. Oi, E. J. Johnston, Z. Konieczna, H. Bhaskar, L. Mendive-Tapia, F. De Moliner, S. J. Rosser, S. G. J. Mochrie, M. Vendrell, M. H. Horrocks and L. Regan, Nano Lett., 2023, 23, 10633–10641. http://doi.org/10.1021/acs.nanolett.3c03780

Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates, R. S. Saleeb, C. Leighton, J.-E. Lee, J. O’Shaughnessy, K. Jeacock, A. Chappard, R. Cumberland, T. Zhao, S. R. Ball, M. Sunde, D. J. Clarke, K. Piché, J. A. McPhail, A. Louwrier, R. Angers, S. Gandhi, P. Downey, T. Kunath and M. H. Horrocks, Sci. Adv., 2023, 9, eadi7359. http://doi.org/10.1126/sciadv.adi7359

Fluorescent Probes for Imaging in Humans: Where Are We Now?, D. Seah, Z. Cheng and M. Vendrell, ACS Nano, 2023, 17, 19478–19490. http://doi.org/10.1021/acsnano.3c03564

Evolution and impact of high content imaging, G. P. Way, H. Sailem, S. Shave, R. Kasprowicz and N. O. Carragher, SLAS Discovery, 2023, 28, 292–305. http://doi.org/10.1016/j.slasd.2023.08.009

Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice,  K. Monsorno, K. Ginggen, A. Ivanov, A. Buckinx, A. L. Lalive, A. Tchenio, S. Benson, M. Vendrell, A. D’Alessandro, D. Beule, L. Pellerin, M. Mameli and R. C. Paolicelli, Nat Commun, 2023, 14, 5749. http://doi.org/10.1038/s41467-023-41502-4

Phenonaut: multiomics data integration for phenotypic space exploration, S. Shave, J. C. Dawson, A. M. Athar, C. Q. Nguyen, R. Kasprowicz and N. O. Carragher, Bioinformatics, 2023, 39, btad143. http://doi.org/10.1093/bioinformatics/btad143

Time-correlated Raman imaging with a SPAD line sensor, N. Finlayson, H. McEwan, G. Brown, A. Gorman, A. Gromov, C. Campbell, A. Erdogan, R. Henderson and G. Williams, in Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, eds. R. R. Alfano and A. B. Seddon, SPIE, San Francisco, United States, 2023, p. 7. http://doi.org/10.1117/12.2648899

Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells, W. H. Skinner, N. Robinson, G. R. Hardisty, H. Fleming, A. Geddis, M. Bradley, R. D. Gray and C. J. Campbell, Chem. Commun., 2023, 59, 3249–3252. http://doi.org/10.1039/D3MD00454F

SERS microsensors for pH measurements in the lumen and ECM of stem cell derived human airway organoids, D. J. Baillache, T. Valero, Á. Lorente-Macías, D. J. Bennett, R. J. R. Elliott, N. O. Carragher and A. Unciti-Broceta, RSC Med. Chem., 2023, 14, 2611–2624. http://doi.org/10.1039/D2CC06582G

Control of cell state transitions, O. S. Rukhlenko, M. Halasz, N. Rauch, V. Zhernovkov, T. Prince, K. Wynne, S. Maher, E. Kashdan, K. MacLeod, N. O. Carragher, W. Kolch and B. N. Kholodenko, Nature, 2022, 609, 975–985. http://doi.org/10.1038/s41586-022-05194-y

Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes, R. E. Hughes, R. J. R. Elliott, X. Li, A. F. Munro, A. Makda, R. N. Carter, N. M. Morton, K. Fujihara, N. J. Clemons, R. Fitzgerald, J. R. O’Neill, T. Hupp and N. O. Carragher, ACS Chem. Biol., 2022, 17, 1876–1889. http://doi.org/10.1021/acschembio.2c00301

Time-correlated Raman and fluorescence lifetime spectroscopy at megahertz repetition rates, H. McEwan, G. E. Brown, A. Usai, A. Erdogan, A. Gorman, C. J. Campbell, R. K. Henderson and N. Finlayson, in Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, ed. Z. Huang, SPIE, San Francisco, United States, 2022, p. 47. http://doi.org/10.1117/12.2609660

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment, J. C. Dawson, A. Munro, K. Macleod, M. Muir, P. Timpson, R. J. Williams, M. Frame, V. G. Brunton and N. O. Carragher, Molecular Oncology, 2022, 16, 1072–1090. http://doi.org/10.1002/1878-0261.13151