Biomolecular core services

Services and equipment for the biomolecular core lab

Viral vectors are highly versatile delivery vehicles that can manipulate gene expression and fluorescently mark cells both in vitro and in vivo.  We maintain in house trial stocks of lentiviral and recombinant adeno-associated (rAAV) vectors, allowing initial testing in your experimental system before tailoring vectors to your specific project requirements.

Our methods and approach are underpinned by extensive expertise, with many years of hands-on experience and publications. We offer a wide range of customisation options, including:

  • Multiple fluorescent tags
  • Selection of promoters and inducibility
  • Overexpression of your gene of interest or knock-down

We offer lentiviral production as a complete service, including DNA maxi-prep (optional) and viral packaging. A formal quote can be provided once you confirm the amount of lentivirus required.

Available formats include:

Concentrated, Serum-Free Lentivirus

  • Charged per production plate
  • Concentrated to 150 µL
  • Typical titre: ≥ 1 × 10⁸ TU/mL, depending on transduction efficiency

Unconcentrated Lentivirus (in Serum)

  • Final volume: ~10 mL
  • Typical titre: ~1 × 10⁶ TU/mL
Row of biological safety cabinets in TC room used for sterile cell culture, lentivirus and recombinant adenovirus work.

We offer a comprehensive qPCR gene expression analysis service, supporting projects from sample processing through to data interpretation. Our workflows can provide accurate, reproducible, and publication-ready results.

Projects can be tailored to your specific genes, species, and experimental conditions.

Our qPCR services include:

  • DNA and RNA extraction from a range of sample types
  • RNA quality assessment and integrity checks
  • cDNA synthesis using validated protocols
  • Housekeeping gene evaluation to identify the most appropriate reference genes for your experimental system
  • qPCR assay setup and optimization
  • qPCR data acquisition and quality control
  • Data normalization, analysis, and interpretation
  • Clear presentation of results, including Ct values, relative expression analysis, and summary figures

All experiments are performed using established best practices, with careful attention to experimental design and controls to ensure robust and reproducible results.

We are happy to support internal and external projects, including pilot studies, validation experiments, and larger gene expression analyses.

QuantStudio 5 real-time PCR instrument.

We offer mass photometry analysis using the Refeyn Two MP, a cutting-edge instrument that measures the mass of individual biomolecules directly in solution. The instrument is ideally suited for particles in the 30 kDa – 5 MDa range, where signal intensity is directly proportional to molecular mass, enabling true mass determination and detailed insight into sample composition.

Suitable applications:

  • Protein and nucleic acid mass determination
  • Assessment of sample purity and heterogeneity
  • Analysis of molecular interactions
  • Characterization of oligomeric states
Mass photometer instrument on laboratory bench. Used for measuring molecular mass of biomolecules in solution.

We offer label-free, real-time biomolecular interaction analysis using the Gator Plus Biolayer Interferometry (BLI) system. This plate-based technique enables rapid and quantitative measurement of binding events between proteins, nucleic acids, antibodies, and other biomolecules.

Suitable applications:

  • Measurement of binding affinity and kinetics (association and dissociation rates)
  • Analysis of biomolecular interactions and specificity
  • Analyte concentration determination
  • Antibody–antigen and protein–protein interaction studies

Compatible with crude and purified samples.

Gator BioLayer Interferometry instrument used for real-time, label-free measurement of biomolecular interactions.

We offer microfluidic DNA and RNA analysis using the LabChip GX Touch 24, an automated bioanalyzer that replaces traditional slab gels for rapid, high-resolution sizing and quantitation.

Samples are analysed using dedicated software that converts fluorescence signals into electropherograms and virtual gel images, providing accurate fragment size and concentration measurements calibrated against internal ladders and markers.

Suitable applications:

  • NGS library quality control
  • qPCR product checks
  • RNA integrity and quality assessment

Available assay kits:

  • High Sensitivity DNA
  • RNA Pico Sensitivity
  • RNA Standard Sensitivity

This service is ideal for fast, reproducible nucleic acid QC with minimal sample input. Contact us for pricing, turnaround times, and sample requirements.

LabChip GX24 instrument used for automated nucleic acid analysis.

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