A review of Lynch syndrome, the most common inherited cancer predisposition syndrome, was published by IRR Researcher Neil Ryan, along with colleagues from across the UK. Immune microenvironment of MMR-deficient tumours and mechanisms of immune evasion in Lynch syndrome. Taken from the review. Lynch syndrome is a common inherited condition caused by faults in the mismatch repair system—a mechanism in our cells that corrects errors when DNA is copied during cell division. It affects about 1 in 400 people and significantly increases the risk of several cancers, particularly colorectal and endometrial (womb) cancers. The review, published in the Lancet, provides an integrated overview of Lynch syndrome across the pathways of care, highlighting advances in biology, diagnosis, prevention, and treatment, while emphasising the need to align scientific progress with equitable and effective health-system delivery. Read the review below: Review: Lynch syndrome Tags CRH This article was published on Friday 13 November 2026
