IRR Seminar: Professor Hartmut Jaeschke

“Paracetamol hepatotoxicity and acute liver failure: Updates on mechanisms and therapeutic interventions”

Professor Hartmut Jaeschke, Department of Pharmacology, Toxicology, & Therapeutics, University of Kansas Medical Center

Professor Jaeschke webpage

Host: Professor James Dear

Biog:

Hartmut Jaeschke, PhD, ATS, FAASLD, is University Distinguished Professor and Past Chairman (2012-2024) of the Department of Pharmacology, Toxicology, and Therapeutics at the University of Kansas Medical Center, Kansas City, Kansas. He joined KUMC in 2006. He is a Fellow of the Academy of Toxicological Sciences (ATS) and Fellow of the American Association for the Study of Liver Diseases (FAASLD). After receiving his PhD degree in toxicology from the University of Tübingen, Germany, in 1983, he did postdoctoral work at the University of Tübingen and Baylor College of Medicine in Houston, Texas, USA. Since 1987, he has held faculty positions at Baylor (1987–1992), the University of Arkansas for Medical Sciences, Little Rock (1999–2002), and the University of Arizona, Tucson (2002–2006). In addition, he spent 6 years in the pharmaceutical industry (The Upjohn Co. and Pharmacia & Upjohn Co., Kalamazoo, MI), from 1992 to 1998. He has published more than 540 peer-reviewed manuscripts, invited reviews, and book chapters in the areas of liver toxicology and liver pathophysiology (“h-factor 135”; >76,000 citations; Google Scholar). Dr. Jaeschke was a standing member of the Hepatobiliary Pathophysiology NIH study section (2008-2013) and served as an ad-hoc member on numerous additional NIH grant review committees. In the past, Dr. Jaeschke served on the Editorial Boards of Hepatology, Journal of Hepatology, American Journal of Physiology: Liver and Gastrointestinal Physiology, and Gastroenterology; he was an Associate Editor for Hepatology (2002–2006) and Liver International (2007–2012). He currently serves as Editor-in-Chief of Livers and as Associate Editor for Toxicological Sciences (since 2014), and 4 other journals. In addition, he is a member of the editorial boards of the American Journal of Pathology, Toxicology Letters, and 10 additional journals. He is a member of many national and international scientific societies including the Society of Toxicology (since 1990) and served as president of Central States Chapter of SOT (CSSOT) (2008/2009), on the Board of Publication of SOT (2007-2011; chair 2009-11) and as councilor (2017-2019) and president (2023-2024) of the Clinical and Translational Specialty Section (CTTSS). He is the recipient of the CSSOT John Doull Award (2015) and the Translational Impact Award (2019) from SOT. His major research interests include basic mechanisms and translational aspects of xenobiotic-induced hepatotoxicity and tissue repair, with a focus on acetaminophen overdose and mechanisms of inflammatory liver injury in animal models and humans.